Primidone 5-ethyldihydro-5, phenyl-4,6(1H,-5H)-pyrimidine-dione is a white crystalline substance, and is a pyrimidine derivative. Studies of chronic administration of primidone indicate it can metabolize into two active metabolites, phenobarbital and phenylethylmalonamide (PEMA). Neurosyn acts upon the central nervous system to raise the seizure threshold, hence its value as an anticonvulsant, whether the seizure is induced electrically or is a symptom of a primary disease process.

Neurosyn is veterinary labeled primidone used as an anticonvulsant only for dogs.

Use in dogs only at a rate of 25 mg per pound of body weight per day. Tablets may be administered whole or crushed and mixed with food. When convulsions are frequent, the daily dosage should be given at one time. Reduction in dosage should always be made gradually and treatment should never be discontinued abruptly.

Do not use in felines. Primidone appears to have specific neurotoxicity in cats. In long-term therapy using primidone there is the possibility of serum alkaline phosphatase (SAP) elevation to slightly above normal. When primidone therapy is discontinued, SAP should return to normal unless the elevation is caused by other abnormal conditions, such as bone disease, healing fractures or pregnancy.

Use only in dogs to treat idiopathic epilespsy, epileptiform convulsions, virus encephalitis, distemper, hardpad disease.

Federal law restricts this drug to use by or on the order of a licensed veterinarian. Keep out of reach of children. For use in animals only.